Physicians: ABOM Exam Prep Part 1

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Example Question, with answer, explanation, and reference. 1. Which gene is located within the Adipocyte with the role of an appetite inhibitor? a. MC4R b. PCSK1 c. LEPR d. FGFRI Answer: LEPR Explanation: LEP (Leptin) is an appetite suppressor which acts on cell receptors in the arcuate nucleus of the hypothalamus. MC4R can be found in adipose tissue, hypothalamus, and liver and leads to appetite stimulation. PCSK1 is a neuroendocrine cell expressed gene located in the pituitary and brain, as well as adrenal glands. FGFR1 is a Fibroblast growth factor receptor 1 located in the hypothalamus and adipose tissue and responsible for regulation of food intake. Reference: https://www.aace.com/sites/default/files/2018-11/1.2.obesity-pathophysiology.pdf

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